September 2021

The event was on

Atlantic: SEPTEMBER 14th 2021

Pacific: SEPTEMBER 16th 2021

Premiere Session
Atlantic

Time:

14th September 2021: 
10.00am New York
15.00 pm London
23.00pm Tokyo

Pacific Second Session
Pacific

Time:

16th September 2021: 
10.30am Tokyo
2.30am London
21.30pm New York (15th September)

KEYNOTE TALK

Permanent hitchhikers:
how human gut microbes diversified with and adapted to their hosts

Abstract:
Coevolution of humans with gut bacteria requires a shared evolutionary history. Host-microbial cophylogeny has been shown for hominids, but within humans, only the stomach bacterium 
Helicobacter pylori is known to have codiversified with its host. Human populations are known to harbor distinct strains of bacterial species and this is generally attributed to differences in environment and diet, however, codiversification through long-term associations could also contribute to these patterns. To test for cophylogeny between gut microbiota and their human hosts, we analyzed paired human genotypes and bacterial strain genotypes from fecal metagenomes obtained from five countries. Our results indicate that strains of common gut bacteria have transmitted vertically for thousands of generations. In accord, strains displaying patterns of cophylogeny are also shared between mothers and infants. Patterns of strain transfer between populations are consistent with an African origin for taxa showing cophylogeny. Our results indicate long-term fidelity of gut microbial strains with human populations, creating opportunities for coevolution.

Prof Ruth E. Ley

Ruth Ley is the Director of the Department of Microbiome Science at the Max Planck Institute for Developmental Biology and a Speaker for the Cluster of Excellence “Controlling Microbiomes to Fight Infection” with the University of Tuebingen, Germany. Since 2020 Ley is on the Scientific Council of the Institut Pasteur. 

CV:
THE LAB:

SELECTED TALKS

Critical Assessment of Metagenome Interpretation - the second round of challenges

Alice McHardy 

See the abstract!

Quantification of gut bacterial strains following fecal transplantation

Varun Aggarwala

See the abstract!

Klebsiella oxytoca mediates colonization resistance against multi-drug resistant Klebsiella pneumoniae in the gut via cooperative carbohydrate competition

Lisa Osbelt

See the abstract!

RESEARCH HIGHLIGHTS

Integrative analysis of gut microbiota, microbial gene expression and function coupled with metabolome to understand mechanisms that influence the development of non-alcoholic fatty liver disease

Ekaterina Smirnova

Virginia Commonwealth University, Richmond, Virginia, USA

See the abstract!

Phage induction gives insight on the Anaerobic Digestion metavirome

Alessandro Rossi 

Università di Padova, Padova, Italy

See the abstract!

Human Lung Microbiota-driven Innate Immune Landscape

Sudip Das

DMF, University of Lausanne, Lausanne, Switzerland

See the abstract!

The aging mouse microbiome has obesogenic characteristics

Dana Binyamin

Bar-Ilan University, Ramat Gan, Israel

See the abstract!

The gut microbiotas influence in the development of Foetal Alcohol Spectrum Disorders

Natasha Kitchin

See the abstract!

When 16s rRNA outperforms WMGS metagenomics

Stanislav Smatana

RECETOX, Masarykova Univerzita, Brno, Czech Republic; VUT, Brno, Czech Republic

See the abstract!

OPEN-ACCESS PAPER HIGHLIGHT

Dispersal strategies shape persistence and evolution of human gut bacteria

Falk Hildebrand

Quadram Institute Bioscience, Earlham Institute, Norwich, United Kingdom 

See the abstract!

Statistical approaches for differential expression analysis in metatranscriptomics

Yancong Zhang

Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, USA

See the abstract!

Precise phylogenetic analysis of microbial isolates and genomes from metagenomes using PhyloPhlAn 3.0

Francesco Asnicar

Department CIBIO, University of Trento, Italy

See the abstract!

Newly Explored Faecalibacterium Diversity Is Connected to Age, Lifestyle, Geography, and Disease

Francesca De Filippis

See the abstract!

Dental Biofilm Microbiota Dysbiosis Is Associated With the Risk of Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation

Vitor Heidrich

Hospital Sírio-Libanês, São Paulo, Brazil

See the abstract!